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Tamiflu Bird Flu Protection - Tamiflu Efficacy Against Influenza
Anti-influenza coverage Of Tamiflu
Tamiflu Efficacy Against Influenza
Covers influenza type A and type B
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Effective against all known influenza strains of these types
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In vitro assays have shown that TAMIFLU inhibits the neuraminidases of both influenza A and B viruses and prevents their replication
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Efficacy was shown in clinical studies conducted worldwide in which the predominant infections were type A and a small number of patients had influenza type B
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Inhibition of viral neuraminidase and virus replication demonstrated in vitro
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Achieves and maintains plasma concentrations above the antiviral IC50 for laboratory strains of influenza A and B for 12 hours after a single 75 mg dose9
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The relationship between the in vitro antiviral activity in cell culture and the inhibition of influenza virus replication in humans has not been established
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There is no evidence for the efficacy of Tamiflu in any illness other than influenza types A and B.
Proven efficacy of Tamiflu in clinical trials
In U.S. phase III study - Significant reduction in flu duration
Multicenter, double-blind, randomized and placebo-controlled studies of 253 otherwise healthy adults aged 18 to 65 years with naturally acquired influenza. Patients were treated with Tamiflu 75-mg bid or placebo bid for 5 days (initiated within 2 days of symptom onset), then monitored for 3 weeks. 12
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Statistically and clinically significant benefits were consistently achieved in studies worldwide
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In an ongoing study of Tamiflu in otherwise healthy elderly patients >65 years (n=168), there was a reduction in influenza duration similar to that seen in younger adults
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Efficacy in high-risk patients has not been established, and there were no differences in the incidence of complications between treatment and placebo groups in this population.
Diminishes the impact of influenza - Reduces duration of fever
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Fever is a hallmark symptom of influenza that is debilitating for patients
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Multicenter, double-blind, randomized and placebo-controlled studies (one in the U.S. and two outside of the U.S.) of 610 otherwise healthy adults aged 18 to 65 years with naturally acquired influenza. Patients were treated with TAMIFLU 75 mg bid or placebo bid for 5 days (initiated within 2 days of symptom onset), then monitored for 3 weeks. 12
Reductions in viral shedding in challenge studies
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Challenge studies support A and B antiviral activity in volunteers who received Tamiflu or placebo shortly after influenza virus inoculation
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Tamiflu dosage information
Tamiflu is asy to prescribe and easy to take with convenient bid capsule dosing
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One 75 mg capsule twice daily for 5 days
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A familiar route of administration
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No patient training required
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Treatment should begin within 2 days of symptom onset
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May be taken with or without food
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The safety and efficacy of repeated treatment or prophylaxis courses have not been established.
WHEN THE BIRD FLU EPIDEMIC STRIKES TAMIFLU SUPPLIES WILL BECOME SCARCE AND THE PRICE WILL SHOOT UP
BE PREPARED FOR THE IMMINENT AVIAN FLU EPIDEMIC
BE PREPARED FOR THE IMMINENT AVIAN FLU EPIDEMIC
DOSAGE
QUANTITY
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75 mg
10 Capsules
$129.00
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$149.00
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75 mg
30 Capsules
$299.00
FREE
$319.00
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